Hypromellose Acetate Succinate

Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS)

Hypromellose Acetate Succinate


SidleyCel® Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS) is mixed ester of HPMC acetate and succinic acid. It is tasteless, white to light yellow powder or granule, and mainly used for enteric coating.


Cas No. 71138-97-1

As enteric coating material, it has good film-forming property without plasticizer, good solubility in the upper part of small intestine (duodenum), thus can increase medicine absorption in small intestine.

It can be well dissolved in acetone, ethanol- dichloromethane, acetone- ethanol- water and other solvents.

Comply with USP33

ITEM Specification
Viscosity (mPa.s) 2.4-3.6
Methoxy (wt, %) 12-28
Free acetic (wt, %) 27.0-35.0
Hydroxypropoxy (wt, %) 4-23
Loss on drying (%) ≤5.0
Residue on ignition (%) ≤0.20
Heavy metals (ppm) ≤10


Content LG MG HG
Acetyl group 5.0-9.0 7-11 10-14
Butyl two acyl group 14-18 10-14 4-8


PACKAGING: 10KG/barrel or 25KG/barrel lined with inner PE bag.

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