Ethyl Cellulose(CAS:9004-57-3) did not dissolve in water, but soluble in many organic solvents were used as tablets, granules of the adhesive, can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, but also can be used as reinforcing material for Sustained Release Tablets.
Technical specification
Comply with USP, EP and CP.
| Item | K grade | N grade |
| Ethoxy (WT%) | 45.5-46.8 | 47.5-49.5 |
| Viscosity (mPa.s) (5% solu., 20℃) | 4, 5, 7, 10, 20, 50, 70, 100, 150, 200, 300 | |
| Loss on drying (%) | ≤3.0 | |
| Residue on ignition (%) | ≤0.4 | |
| Chloride (%) | <0.1 | |
| Heavy metals (ppm) | ≤20 | |
| Arsenic (ppm) | ≤3 | |
Ethyl Cellulose pharmaceutical Application Guide
Ethyl Cellulose because it did not dissolve in water, but soluble in many organic solvents were used as tablets, granules of the adhesive, can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, but also can be used as reinforcing material for Sustained Release Tablets.
Application suggestion
| Specification | Reference usage | Applications |
| N-7,N-10,N-20 | 3-20% | Sustained-release coating, to provide a good diffusion membrane and can also adjust the mix of water-soluble HPMC proliferation rate. |
| N-20,N-50,N-100 | 10-20% | Microcapsules |
| N-7,N-10,N-20 | 1-5% | Floating layer tablets, used as an organic solvent to form a solid coating with good adhesive film, a masking role of Smell. Often mixed with HPMC. |
| N-10,N-20 | 2-6% | Tablet granulation binder, used as a solvent for water-sensitive drug granulation, the production has a good dissolution properties of solid tablets. The thermoplastic extrusion granulation help. |
Organic solvent method of solubility and dissolution
Ethyl Cellulose can be dissolved in various organic solvents, such as ethanol, isopropyl alcohol, other alcohols, ketones, aromatic and so on. Common solvent (volume ratio):
*Toluene: Ethanol = 4:1
*Ethanol
*Acetone: Isopropanol = 65:35
*Toluene: Isopropanol = 4:1
*Methyl Acetate: Methanol = 85:15
Alcohols and aromatics in the viscosity of the mixture, going down with alcohol content higher, when alcohol accounts for 30-35%, the lowest viscosity of the composition. Dissolution method: the Ethyl Cellulose under the stirring slowly add the container filled with a solvent until complete wetting dissolved.
