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High-Substitute Hydroxypropyl Cellulose

01 Overview

Hydroxypropyl cellulose (HPC) is a non-ionic, water-soluble cellulose ether possessing numerous properties. It dissolves in organic solvents, exhibits good thermoplasticity, and has low surface activity in solution. Like other water-soluble cellulose polymers, it acts as a thickener and stabiliser in aqueous solutions. HPC films demonstrate excellent flexibility, requiring no plasticiser addition in film coating applications.

High-Substitute Hydroxypropyl Cellulose(H-HPC)

Brief Introduction

SidleyCel® H-HPC can be used as a binder in pharmaceutical field such as tablet and particle binder, which can increase the stability and hardness of tablets. H-HPC has excellent film-forming property and film can be tenacious and elastic. It’s also an excellent film coating material.High-viscosity, highly substituted hydroxypropyl cellulose (HPC) serves as an exceptional hydrophilic gel sheet framework material. Compared to HPMC, a notable advantage of HPC is its excellent compressibility, thereby yielding superior performance in dry granulation processes.

Technical Specifications

Item Unit Standard
Hydroxypropoxy % 55.0~77.0
Loss on drying % ≤7.0
Residue on ignition % ≤1.0
PH 5.0~8.0

 

Types Viscosity Concentration in water,Weight,%
M 4000-6500 2%
G 150-400 2%
J 150-400 5%
L 75-150 5%

Package and storage

25KG/barrel; or customized packing.

02 HPC vs. L-HPC

Although L-HPC and HPC share the same CAS number, L-HPC differs from HPC. L-HPC possesses distinct properties from HPC, which is a widely used binder in solid dosage forms. L-HPC and HPC are each described in separate chapters within the pharmacopoeia. Conventional HPC possesses a substantial quantity of hydroxypropoxyl groups on its cellulose backbone, whereas L-HPC contains only a limited amount. Due to this chemical distinction, HPC is soluble in water, but L-HPC is insoluble. HPC aqueous solutions are typically employed as granulation binders, but L-HPC cannot be utilised in this manner. L-HPC serves as an effective disintegrant due to its expansion in water, whereas HPC does not exhibit this property. Given L-HPC’s concurrently favourable compressibility, dry blending this excipient yields tablets with hardness comparable to those prepared with microcrystalline cellulose. In this application, L-HPC functions as a ‘dry binder’.

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